| Synonym |
Des-gamma carboxyprothrombin (DCP) |
| Specimen
requirement |
Adult patient:
Clotted blood tube (Serum gel separator clot activator tube)
Minimum blood volume: 5 mL |
| Authorisation code
required |
No (request by NTEC hepatologists ONLY) |
| 24 Hr available
service |
No |
|
| Method |
Immunoassay |
| Reference interval |
<= 28.4 ng/ml
For subjects aged 18 years old or above
(Source: from manufacturer’s kit insert) |
| Clinical indication |
PIVKA-II in combination with AFP improves the detection of hepatocellular carcinoma (HCC). |
| Result interpretation |
Using a cut-off of 28.4 ng/ml (95th percentile in an apparently healthy population), Roche PIVKA-II assay detected HCC with 86.9% sensitivity and 83.7% specificity. |
| Measurement of
uncertainty |
- |
| Frequency of
measurement |
Daily |